TOX A/B QUIK CHEK® has a larger sample well to make
testing for C. difficile toxins A and B fast, easy,
accurate, and clean.
Easy to Use
- A larger sample well means neater, quicker placement.
- Novel patent-pending technology smoothly disperses sample
within the device.
- The chance of clogging is minimized, greatly reducing unwanted
spillovers.
Easy to Read
- Two lines mean C. difficile toxin A/B is present
- Internal control line validates the QC result in the same
reaction window
Highly Accurate
- >90% sensitivity*
- >99% specificity*
TOX A/B QUIK CHEK® Testing Procedure
Download sample Procedure Card
About C. difficile
Clostridium difficile is a gram-positive, spore-forming
anaerobic bacterium. C. difficile is the leading cause of
diarrhea outbreaks or C. difficile-associated disease
(CDAD) in hospitals, infirmaries, and elderly care units. CDAD is
usually caused by antibiotic or chemotherapy disturbing the normal
balance of the gut flora.1 Virtually any antibiotic is
capable of causing the condition and studies have shown reduced
antibiotic prescription levels can significantly reduce CDAD
cases.2 Outbreaks in nosocomial environments are
difficult to control since the bacteria produces spores that are
difficult to eradicate.2
C. difficile has been identified as the organism
responsible for toxin production.3 C. difficile
produces two large molecular weight toxins, designated A and B.
Toxin A is considered to play a more important role in the etiology
of CDAD.4 The toxins produce symptoms in CDAD patients,
which can range from mild diarrhea to pseudomembranous colitis
(PMC). PMC manifests as adherent yellowish-white plaques on the
intestinal mucosa. Rapid diagnosis of C. difficile is
therefore important in order to treat patients and prevent spread
of the disease.2
References
- Hamm L. Clostridium difficile. Pediatr Pharm.
2000;6(6).
- McNulty C, Logan M, Donald IP, et al. Successful control of
Clostridium difficile in an elderly care unit through use
of a restrictive antibiotic policy. J Antimicrob Chemother. 1997;
40:707-711.